Detailed view for TVAG_485930

Basic information

TDR Targets ID: 846358
Trichomonas vaginalis, Root-specific lectin precursor, putative
Source Database / ID: 

pI: 6.4175 | Length (AA): 224 | MW (Da): 23699 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128415)

Species Accession Gene Product
Brugia malayi Bm1_57400   EGF-like domain containing protein
Caenorhabditis elegans CELE_Y64G10A.7   Protein Y64G10A.7, isoform B
Drosophila melanogaster Dmel_CG2086   draper
Echinococcus granulosus EgrG_000068100   laminin
Echinococcus multilocularis EmuJ_000068100   laminin
Homo sapiens 1953   multiple EGF-like-domains 6
Homo sapiens ENSG00000145794   multiple EGF-like-domains 10
Homo sapiens ENSG00000187800   platelet endothelial aggregation receptor 1
Homo sapiens ENSG00000157890   multiple EGF-like-domains 11
Leishmania braziliensis LbrM.28.2570   subtilisin-like serine peptidase,serine peptidase, clan SB, family S8-like protein
Leishmania donovani LdBPK_282540.1   subtilisin-like serine peptidase
Leishmania infantum LinJ.28.2540   subtilisin-like serine peptidase,serine peptidase, clan SB, family S8-like protein
Leishmania major LmjF.28.2380   subtilisin-like serine peptidase,serine peptidase, clan SB, family S8-like protein
Leishmania mexicana LmxM.28.2380   subtilisin-like serine peptidase,serine peptidase, clan SB, family S8-like protein
Loa Loa (eye worm) LOAG_07472   multiple epidermal growth factor-like domains 6
Loa Loa (eye worm) LOAG_06602   hypothetical protein
Mus musculus ENSMUSG00000057751   multiple EGF-like-domains 6
Mus musculus ENSMUSG00000024593   multiple EGF-like-domains 10
Mus musculus ENSMUSG00000036466   multiple EGF-like-domains 11
Mus musculus ENSMUSG00000028073   platelet endothelial aggregation receptor 1
Neospora caninum NCLIV_001350   EGF-like domain-containing protein, putative
Schistosoma japonicum Sjp_0054220   Multiple epidermal growth factor-like domains 6 precursor, putative
Schistosoma japonicum Sjp_0134560   Matrilin-2 precursor, putative
Schistosoma japonicum Sjp_0100200   IPR006209,EGF-like;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and asparagine hydroxylation site;IP
Schistosoma japonicum Sjp_0053060   hypothetical protein
Schistosoma mansoni Smp_135210   egf-like domain protein
Schmidtea mediterranea mk4.011108.02   Pre-mRNA-processing factor 19 homolog
Schmidtea mediterranea mk4.017714.00  
Schmidtea mediterranea mk4.000532.12   Multiple epidermal growth factor like domains protein-1
Trichomonas vaginalis TVAG_485930   Root-specific lectin precursor, putative
Trichomonas vaginalis TVAG_220940   Metallothionein, putative
Trichomonas vaginalis TVAG_182840   Keratin-associated protein 5-7, putative
Trichomonas vaginalis TVAG_486210   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_485930 (Trichomonas vaginalis), Root-specific lectin precursor, putative
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